23rd Jun 2022 https://nfind.uk/lockdown_exit/index.php/newsletter=687 lockdown_exit

Lockdown Exit

Sky News Britons will have access to all the latest vaccines and treatments when a new research and manufacturing centre opens in the UK. American pharmaceutical giant Moderna is opening a new mRNA Innovation and Technology Centre that will develop vaccines for a wide range of respiratory diseases including COVID vaccines that can protect against multiple variants. Construction is expected to start as early as this year with the first mRNA vaccine due to be produced in the UK in 2025. https://news.sky.com/story/covid-19-britons-to-have-first-access-to-vaccines-and-treatments-when-new-science-super-centre-opens-12638186 22nd Jun 2022

Lockdown Exit

South China Morning Post Women have borne the brunt of hardship two years after the pandemic facing less access to vaccines and food and taking on more domestic work a new UN report shows. Experts say that gender policies must be implemented to ensure that women and girls are included in the recovery taking place across Asia and the Pacific https://www.scmp.com/week-asia/people/article/3182486/indonesia-pacific-women-less-likely-have-2-covid-19-vaccine-shots 22nd Jun 2022

Lockdown Exit

CNN The US Centers for Disease Control and Prevention updated its travel advisory page for Covid19. Just two new places both in Africa joined the crowded high risk category. https://www.cnn.com/travel/article/cdc-covid-travel-risk-destinations-june-21/index.html 22nd Jun 2022

Lockdown Exit

Reuters Babies and toddlers began getting the COVID19 vaccine in thighs and arms across the United States on Tuesday in many cases in front of cameras and a masked cheering audience. https://www.reuters.com/video/watch/idsKNx?now=true 22nd Jun 2022

Lockdown Exit

Reuters The Universal Beijing Resort said on Wednesday it will reopen on June 25 after being closed for nearly two months as the number of new COVID19 cases in the Chinese capital falls. The resort said on its official WeChat account that after it reopens all visitors must show a negative PCR test taken within the past 72 hours and wear masks at all times. https://www.reuters.com/world/china/universal-beijing-resort-reopen-june-25-covid-cases-drop-2022-06-22/ 22nd Jun 2022

Lockdown Exit

The Wall Street Journal In the US federal health authorities on Saturday recommended Modernas twodose vaccine as well as a threedose regimen by Pfizer and BioNTech for children as young as 6 months. It was a moment some parents and caregivers had been eagerly awaiting yet some of them havent managed to book appointments for their children while others are holding off. https://www.wsj.com/articles/as-kids-under-5-start-getting-the-covid-19-vaccine-parents-struggle-to-find-appointments-11655899200 22nd Jun 2022

Lockdown Exit

Bloomberg Donors including the US and the European Union have pledged 1.1 billion in financing to help countries cope with future pandemics. Indonesia as this years host of the Group of 20 meetings pushed the worlds biggest economies to create a global health fund that would aid nations struggling with the next global health crises said Finance Minister Sri Mulyani Indrawati in a late Tuesday briefing. The Southeast Asian country is also among the donors along with Germany Singapore and the Wellcome Trust Health Minister Budi Gunadi Sadikin said after the G20 meeting of health and finance ministers in Yogyakarta. The goal is to reach 10 billion of financing each year he added. The fund is set to start operating after an expected June 30 approval from the board of the World Bank which is hosting the financing mechanism. bloomberg.com/news/articles/2022-06-21/-1-1-billion-pledged-to-help-countries-cope-with-future-pandemic?srnd=premium-uk 21st Jun 2022

Exit Strategies

MSN.com Manitoba is seeking input on its plans to vaccinate children under the age of five against COVID19. Vaccines for children aged six months to four years old could be approved by Health Canada this summer. In anticipation of this the province has launched a survey asking for feedback on how the rollout should look particularly from parents with children in this age group says a news release form the province. https://www.msn.com/en-ca/news/canada/manitoba-government-launches-survey-on-covid-19-immunization-plans-for-children-under-5/ar-AAYKkay 22nd Jun 2022

Exit Strategies

iNews Covid jabs firm Moderna is opening the first ever factory making mRNA vaccines in the UK the Government has announced. The company will make the next generation of coronavirus jabs protecting against multiple variants as well as new vaccines against illnesses such as flu. https://inews.co.uk/news/politics/moderna-will-make-covid-19-vaccines-in-uk-for-the-first-time-as-it-plans-mrna-factory-to-create-future-jabs-1699304 22nd Jun 2022

Exit Strategies

Reuters U.S. biotech firm Moderna will build a new research and manufacturing centre in Britain to develop vaccines against new COVID19 variants other respiratory illnesses and help improve readiness for any future pandemics. The agreement will see Moderna make a minimum RD investment of 1.1 billion pounds 1.35 billion Prime Minister Boris Johnsons spokesman said adding it would have the capacity for 250 million vaccines a year if needed. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-build-new-vaccine-facility-britain-2022-06-21/ 22nd Jun 2022

Exit Strategies

Reuters Denmark plans to offer a fourth COVID19 vaccine dose in the autumn to those who are over 50 years old Prime Minister Mette Frederiksen said on Wednesday as she announced a strategy to curb the spread of the disease over the coming months. Although COVID infections are still at low levels Denmark has seen an increase in the number of cases after the new BA.5 subvariant of Omicron which seems to spread more quickly than other variants became dominant in the Nordic country. https://www.reuters.com/world/europe/denmark-offer-fourth-covid-vaccine-dose-people-over-50-years-2022-06-22/ 22nd Jun 2022

Exit Strategies

Yahoo Finance A new Government partnership with vaccine manufacturer Moderna will bring over a billion pounds in investment in mRNA research to the UK the Health Secretary has said. The US pharmaceutical giant announced on Wednesday plans to open a new research and manufacturing centre in the UK. The new mRNA Innovation and Technology Centre will develop vaccines for a wide range of respiratory diseases including Covid vaccines that can protect against multiple variants https://uk.finance.yahoo.com/news/government-moderna-partnership-bring-over-105731545.html 22nd Jun 2022

Exit Strategies

The Wall Street Journal Anna Carvill had one thing on top of her todo list this week get a Covid19 vaccine appointment for her 2yearold son. She managed to get an appointment for Thursday at a mobile clinic in downtown Boulder Colo. Vaccines became available Monday. She is one of millions of parents and caregivers who are seeking to get their children under 5 vaccinated against Covid19. We want him to be as protected as he can as soon as possible Ms. Carvill said. Federal health authorities on Saturday recommended Moderna Inc.s twodose vaccine as well as a threedose regimen by Pfizer Inc. and BioNTech SE for children as young as 6 months. It was a moment some parents and caregivers had been eagerly awaiting yet some of them havent managed to book appointments for their children while others are holding off. https://www.wsj.com/articles/as-kids-under-5-start-getting-the-covid-19-vaccine-parents-struggle-to-find-appointments-11655899200 22nd Jun 2022

Exit Strategies

Yahoo UK & Ireland COVID19 cases have surged by nearly half in a week official figures show. Last week an estimated 1415600 people had coronavirus in the UK up 425800 or 43. This is the highest estimate for infections since the start of May but is still well below the record high of 4.9 million at the end of March. Cases rose in all four nations of the UK and increased across all age groups. In England around one in 50 people had the virus according to the coronavirus infection survey by the Office for National Statistics ONS. https://uk.sports.yahoo.com/news/covid-19-infections-rise-nearly-121000330.html 22nd Jun 2022

Scientific Viewpoint

The Economist Dr Sheldricks team published their analysis on June 20th in the American Journal of Therapeutics. It was motivated by concerns that other researchers had raised earlier about one particular pattern in the Sputnik V paper the vaccines efficacy was almost identical in each of the five age groups shown. The Russian scientists answer was that these results reflected a true efficacy that did not differ by age. But clinical trials are usually affected by all sorts of random circumstances known as noise in the jargon. The implication is that in this particular trial the various sources of noise cancelled one another out in a way that generated a pattern of equivalent efficacy in all age groups. https://www.economist.com/science-and-technology/2022/06/22/are-the-russian-covid-vaccine-results-accurate 22nd Jun 2022

Scientific Viewpoint

The Brussels Times Immunocompromised patients tend to develop chronic coronavirus infections leading to highly mutated variants that bear multiple antibodyresistant mutations according to a new study carried out by a research team at Tel Aviv University Israel. The study involved an examination of chronic COVID19 patients at the Tel Aviv Sourasky Medical Center Ichilov Hospital and was published this week in Nature Medicine. The researchers found that a weakened antibody response particular in the lower airways of these chronic patients may prevent full recovery from the virus and drive the virus to mutate many times during a lengthy infection. They explained that the virus ability to survive and reproduce in the immunosuppressed patients body without restriction leads to the evolution of many variants. https://www.brusselstimes.com/243167/covid-19-risk-of-mutated-variants-among-immunocompromised-patients-new-study-shows 22nd Jun 2022

Scientific Viewpoint

The Pharma Letter The Drugs Controller General of India DCGI recently approved Biological Es Corbevax vaccine as the first heterogeneous COVID19 booster vaccine in India for adults above 18 years who have received two shots of Covaxin or Covishield. Corbevax has the added advantage of scalability and thermostability making it suitable for deployment in lowresource settings says GlobalData. https://www.thepharmaletter.com/article/biological-e-has-place-in-india-s-covid-19-vaccine-market-following-corbevax-approval 22nd Jun 2022

Scientific Viewpoint

Pharmaceutical Technology Afrigen Biologics has signed an agreement with the Univercells Group to develop the first Africanowned Covid19 vaccine. The partnership will focus on developing a new messenger ribonucleic acid mRNA vaccine leveraging intellectual property IP from both parties as well as a new IP and boosting access to the shot. mRNA specialist eTheRNA will extend support to Afrigen and Univercells in the partnership. The firms will jointly work to address two key challenges the lack of domestic costefficient manufacturing and the requirement for cold or supercold chains. https://www.pharmaceutical-technology.com/news/afrigen-univercells-covid-vaccine/ 22nd Jun 2022

Scientific Viewpoint

Financial Times Although the vaccine did not elicit as many antibodies to the new subvariants as it did to the original Omicron suggesting its efficacy may already be declining Moderna still feels there would be more of a benefit than not https://www.ft.com/content/b9109f23-896a-48eb-8de5-1694ac7b57ba 22nd Jun 2022

Scientific Viewpoint

ABC News Omicron subvariants BA.4 and BA.5 are becoming the dominant forms of COVID19 in Australia and abroad. New data from Moderna shows an updated booster tailored to Omicron generates high levels of antibodies against BA.4 and BA.5. Modernas chief medical officer says pending approval the new booster could be supplied to Australia in August https://www.abc.net.au/news/health/2022-06-22/covid-vaccine-omicron-ba4-ba5-subvariants-antibodies-moderna/101170614 22nd Jun 2022

Scientific Viewpoint

News-Medical.Net Janus kinase JNK inhibitors with antiviral and antiinflammatory properties have shown promising outcomes in treating symptomatic coronavirus disease 2019 COVID19 patients. In a systematic review article published in the journal Cochrane Database of Systematic Reviews scientists have described the clinical outcomes in hospitalized COVID19 patients who have been treated with JNK inhibitors together with standard of care. https://www.news-medical.net/news/20220622/Scientists-evaluate-JNK-inhibitors-in-treating-moderate-to-severe-COVID-19-patients.aspx 22nd Jun 2022

Scientific Viewpoint

The BMJ Although the overall course of the pandemic has been similar across the UK there have been instances when the countries trajectory has diverged. In the first wave Northern Ireland had far fewer deaths and hospital admissions. Lockdown restrictions were similar across the UK at this time. One possible explanation for the divergence is that lockdown began at a slightly earlier stage in the pandemic in Northern Ireland reducing the size of the peak there. In the second wave Scotland had relatively fewer cases hospital admissions and deaths than England and Wales. Scotland also had the most consistent set of restrictions in place between September and December 2020 which may have helped to delay the spread of the alpha variant which was dominant in England by the beginning of December but not in Scotland until January 2021.34 Northern Ireland had a slightly later peak in cases in this wave which may have contributed to lower mortality as a result of the vaccination programme reducing severe disease. Northern Irelands younger population may also have been a factor in its lower cumulative mortality. From the middle of 2021 to February 2022 Northern Ireland had consistently higher rates of hospital admission for covid19 than elsewhere in the UK although case rates and mortality have been broadly similar. This suggests that hospital care for patients with covid19 may have been organised differently in Northern Ireland resulting in a higher admission rate. Another possibility is that hospital acquired covid19 which has been a significant concern5 may be a particular problem in hospitals in Northern Ireland. In February and March 2022 Scotland had the highest case rates and a rapid increase in hospital admissions despite retaining restrictions longest in response to omicron. https://www.bmj.com/content/377/bmj.o1482 22nd Jun 2022

Scientific Viewpoint

Reuters Moderna Inc said on Wednesday that an updated version of its COVID19 vaccine designed to target the Omicron variant also generated a strong immune response against the fastspreading Omicron subvariants BA.4 and BA.5 which have gained a foothold in the U.S. in recent weeks. The updated vaccine which Moderna is hoping will be approved for use as a booster shot for the fall is a bivalent vaccine meaning it contains vaccine designed to target two different coronavirus variants the original variant from 2020 and the Omicron variant that was circulating widely last winter. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-booster-candidate-produces-strong-antibodies-against-omicron-subvariants-2022-06-22/ 22nd Jun 2022

Scientific Viewpoint

Reuters Pfizer Incs blockbuster COVID19 treatment Paxlovid violates an Enanta Pharmaceuticals Inc patent for its COVID drug still in development according to a lawsuit filed Tuesday in Boston federal court. Watertown Massachusettsbased Enanta told the court it received the patent for its antiviral medication last week based on applications dating from July 2020. The company said it began human testing for its oncedaily oral COVID treatment in February and that the Food and Drug Administration fasttracked its review in March. Enanta requested an unspecified amount of money damages from Pfizer including royalties. It also said in a statement that it was not asking the court to block Pfizer from selling Paxlovid. Paxlovid is an oral antiviral pill for highrisk patients that is intended to stave off serious complications from COVID19. Pfizer said last month it expects to make 22 billion from Paxlovid sales this year. The company did not immediately respond to a request for comment on the lawsuit. https://www.reuters.com/legal/government/pfizer-sued-patent-infringement-over-covid-19-drug-paxlovid-2022-06-21/ 22nd Jun 2022

Scientific Viewpoint

Reuters Modernas COVID19 variant vaccine will be ready to ship in August as the company has been making shots ahead of approval Chief Executive Stephane Bancel told Reuters on Wednesday adding that the only bottleneck to supply was a regulatory one. Our goal is as early as August given were going to file all the data in June by the end of June... hopefully in the August timeframe the vaccine is authorised Bancel said in an interview. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-ceo-covid-variant-vaccine-be-ready-shipping-august-2022-06-22/ 22nd Jun 2022

Scientific Viewpoint

The Wall Street Journal The shot targeting both Omicron and the original virus strain produced a strong immune response against subvariants BA.4 and BA.5 the company said https://www.wsj.com/articles/modernas-new-covid-19-shot-shows-promise-against-omicron-subvariants-11655907057 22nd Jun 2022

Scientific Viewpoint

CIDRAP Women are significantly more likely than men to experience long COVID with symptoms that follow a distinct clinical pattern researchers reported today. They said more efforts are needed to explore sex differences in outcomes including greater risks of exposure for some jobs. The researchers from the Johnson Johnson Office of the Chief Medical Officer reported their findings yesterday in Current Medical Research and Opinion a peerreviewed journal. https://www.cidrap.umn.edu/news-perspective/2022/06/women-more-likely-have-long-covid-different-symptom-profile 22nd Jun 2022

Scientific Viewpoint

Reuters Nearly 1 in 5 American adults who reported having COVID19 in the past are still having symptoms of long COVID according to survey data collected in the first two weeks of June U.S. health officials said on Wednesday. Overall 1 in 13 adults in the United States have long COVID symptoms lasting for three months or more after first contracting the disease and which they did not have before the infection the data showed. https://www.reuters.com/business/healthcare-pharmaceuticals/nearly-1-5-adults-who-had-covid-have-lingering-symptoms-us-study-2022-06-22/ 22nd Jun 2022

Scientific Viewpoint

Bloomberg Britains poliofree status could be at risk for the first time in almost two decades after several samples of vaccinederived poliovirus were found during routine London sewage testing. Several closely related viruses were found in samples taken in north and east London between February and May. The findings suggest some spread between closely linked individuals and the virus has continued to evolve and is now classified as a vaccinederived poliovirus type 2 the UK Health Security Agency said Wednesday. Polio can on rare occasions cause serious illness such as paralysis in people are not fully vaccinated. No cases of polio or associated paralysis have been reported according to the agency. https://www.bloomberg.com/news/articles/2022-06-22/uk-s-polio-status-at-risk-as-close-virus-found-in-london-sewage 22nd Jun 2022

Scientific Viewpoint

Reuters People in socially and economically disadvantaged regions are about half as likely to receive an oral antiviral COVID19 pill than residents of wealthier zip codes according to a U.S. government study published on Tuesday. The findings by the U.S. Centers for Disease Control and Prevention CDC revealed this disparity even as there were more dispensing sites located in highvulnerability U.S. zip codes than in the more advantaged areas. https://www.reuters.com/business/healthcare-pharmaceuticals/more-vulnerable-people-receiving-fewer-covid-pills-us-study-2022-06-21/ 21st Jun 2022

Coronavirus Resurgence

South China Morning Post on MSN.com The health ministry said on Tuesday night that the proportion of BA.4 and BA.5 infections is rising contributing to about a third of Singapores Covid19 cases. This compared to 17 per cent 8 per cent and 3 per cent in the previous three weeks. Singapore was hit by the Omicron wave earlier this year and saw close to 20000 daily infections the bulk of them being the BA.2 subvariant. On Tuesday it reported 7109 cases. https://www.msn.com/en-xl/news/other/singapore-s-covid-19-infections-rise-amid-new-subvariants-but-no-change-to-rules-although-health-ministry-urges-boosters/ar-AAYJJLe 22nd Jun 2022

Coronavirus Resurgence

The Guardian Though rare at the start of the pandemic reinfections have become increasingly common as the months and years wear on particularly since the arrival of Omicron which prompted a 15fold increase in the rate of reinfections data from the Office for National Statistics suggests. In part this is because of a decline in protective antibodies triggered by infection andor vaccination over time but the virus has also evolved to evade some of these immune defences making reinfection more likely. https://www.theguardian.com/world/2022/jun/22/uk-worried-rising-covid-infections 22nd Jun 2022

Coronavirus Resurgence

Focus Taiwan News Channel The 4yearold girl was taken to the hospital on June 14 after developing a fever and muscle spasms. She tested positive for COVID19 and was diagnosed with encephalitis or inflammation of the brain. Her condition continued to deteriorate after she was admitted to an intensive care unit ICU the next day. She later developed liver kidney and brainstem dysfunction and passed away due to sudden bleeding in her lungs on June 17 the CECC said. The new MISC case is a 9yearold boy who tested positive for COVID19 on May 19. He initially had a threeday fever stuffy nose and a headache but soon recovered. https://focustaiwan.tw/society/202206220012 22nd Jun 2022

Coronavirus Resurgence

Business Standard New Zealand recorded 5499 new community cases of Covid19 with 18 more deaths the Ministry of Health said on Wednesday. Among the new community infections 1637 were reported in the largest city Auckland the ministry was quoted as saying by Xinhua news agency. In addition 78 new cases of Covid19 were detected at the New Zealand border. Currently 334 Covid19 patients are being treated in hospitals including four in intensive care units or high dependency units. https://www.business-standard.com/article/international/new-zealand-reports-5-499-new-covid-19-community-cases-18-deaths-122062200286_1.html 22nd Jun 2022

Coronavirus Resurgence

Business Standard Singapore reported 7109 new COVID19 cases as of noon on Tuesday comprising 6393 local infections and 716 imported ones. A monkeypox infection has also been confirmed according to media reports. There have been 1378090 coronavirus cases and 1405 deaths in Singapore since the start of the pandemic. Singapore has seen a 23 per cent weekonweek increase in COVID19 community infections largely driven by increased spread of newer Omicron subvariants BA.4 and BA.5 said the Ministry of Health MOH. Although the BA.2 subvariant still accounts for the bulk of Singapores COVID19 infections the Health Ministry said the proportion of BA.4 and BA.5 infections is rising. https://www.business-standard.com/article/international/singapore-reports-7-109-new-covid-19-cases-and-one-monkeypox-infection-122062200129_1.html 22nd Jun 2022

Coronavirus Resurgence

Reuters Chinese capital Beijing reported three new local COVID19 cases on Wednesday as of 3 p.m. all found during community screening a local health official said. Uncertainty over Beijing citys COVID prevention and control situation has increased with new community cases emerging continuously Liu Xiaofeng deputy director at Beijing Center for Disease Prevention and Control told a news briefing. The three infections were found in the citys economictechnological development zone Liu said. https://www.reuters.com/world/china/beijing-city-reports-three-local-covid-cases-wednesday-3-pm-2022-06-22/ 22nd Jun 2022

Coronavirus Resurgence

Reuters France is facing a new wave of COVID19 infections fuelled by new variants of the disease French vaccination chief Alain Fischer said on Wednesday as daily new cases reached an almost twomonth peak the day before at more than 95000. Speaking on France 2 television he said there was no doubt there was once again an upsurge of the pandemic in the country adding he was personally in favour of reinstating mandatory face mask wearing on public transport. https://www.reuters.com/world/europe/france-is-facing-new-covid-19-wave-french-vaccination-chief-2022-06-22/ 22nd Jun 2022

Coronavirus Resurgence

Bloomberg New York City Mayor Eric Adams and health officials lowered the citys Covid19 alert level to medium from high Tuesday citing declining case counts and hospitalization rates. The shift comes a little more than a month after the city moved the Covid19 alert level to high as a wave of new cases spread throughout the city. Day after day New Yorkers are stepping up and doing their part and because of our collective efforts we are winning the fight against Covid19 Adams and City Health Commissioner Ashwin Vasan said in a joint statement. https://www.bloomberg.com/news/articles/2022-06-21/new-york-city-lowers-covid-19-risk-level-to-medium-as-cases-drop 22nd Jun 2022